Targeting the NLRP3 inflammasome alleviates the comorbidity of chronic pain and depression via enhancing the autophagy

Abstract The comorbidity of chronic pain and depression exhibits the bidirectional relationship and forms a vicious cycle in disease development, diagnosis and therapy. NLRP3 inflammasome-mediated neuroinflammation is a crucial factor for the pathogenesis of pain and depression. The underlying mecha...

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Hlavní autoři:	Peigen Zhang, Hongyan Liu, Jingjing Zhou, Shicong Wu, Cancan Song, Dongshan Zhao, Shuang Guo, Hui Gao, Haili Zhu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-01-01
Edice:	Scientific Reports
Témata:	Comorbidity of chronic pain and depression NLRP3 inflammasome MCC950 Autophagy Neuroinflammation
On-line přístup:	https://doi.org/10.1038/s41598-026-35400-0
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