Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions.
<h4>Background</h4>Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans.<h4>Methodology/principal findings</h4>Here we report the discovery of the in vivo antiprion activity of Guanabenz (GA), an agonist of alpha2-adrenergic receptors routinely us...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science (PLoS)
2008-04-01
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| Schriftenreihe: | PLoS ONE |
| Online-Zugang: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18431471/pdf/?tool=EBI |
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