Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions.

<h4>Background</h4>Prion-based diseases are incurable transmissible neurodegenerative disorders affecting animals and humans.<h4>Methodology/principal findings</h4>Here we report the discovery of the in vivo antiprion activity of Guanabenz (GA), an agonist of alpha2-adrenergic receptors routinely us...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Déborah Tribouillard-Tanvier, Vincent Béringue, Nathalie Desban, Fabienne Gug, Stéphane Bach, Cécile Voisset, Hervé Galons, Hubert Laude, Didier Vilette, Marc Blondel
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2008-04-01
Serier:	PLoS ONE
Online adgang:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18431471/pdf/?tool=EBI
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!