Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis

ABSTRACT Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The basis for this conditional drug susceptibility remains undefined. In this study, we utilized a genome-wide...

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Ngā kaituhi matua:	Joshua M. Thiede, Nicholas A. Dillon, Michael D. Howe, Ranee Aflakpui, Samuel J. Modlin, Sven E. Hoffner, Faramarz Valafar, Yusuke Minato, Anthony D. Baughn
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	American Society for Microbiology 2022-02-01
Rangatū:	mBio
Ngā marau:	cell envelope drug discovery drug resistance mechanisms genomics metabolism tuberculosis
Urunga tuihono:	https://journals.asm.org/doi/10.1128/mbio.00439-21
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!