Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis

ABSTRACT Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The basis for this conditional drug susceptibility remains undefined. In this study, we utilized a genome-wide...

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Autori principali:	Joshua M. Thiede, Nicholas A. Dillon, Michael D. Howe, Ranee Aflakpui, Samuel J. Modlin, Sven E. Hoffner, Faramarz Valafar, Yusuke Minato, Anthony D. Baughn
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2022-02-01
Serie:	mBio
Soggetti:	cell envelope drug discovery drug resistance mechanisms genomics metabolism tuberculosis
Accesso online:	https://journals.asm.org/doi/10.1128/mbio.00439-21
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