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Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis

ABSTRACT Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The basis for this conditional drug susceptibility remains undefined. In this study, we utilized a genome-wide...

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Principais autores: Joshua M. Thiede, Nicholas A. Dillon, Michael D. Howe, Ranee Aflakpui, Samuel J. Modlin, Sven E. Hoffner, Faramarz Valafar, Yusuke Minato, Anthony D. Baughn
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2022-02-01
Serier:mBio
Fag:
cell envelope
drug discovery
drug resistance mechanisms
genomics
metabolism
tuberculosis
Online adgang:https://journals.asm.org/doi/10.1128/mbio.00439-21
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