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Circular mRNA against CleanCap linear mRNA vectors: comprehensive comparison, expression, active and passive immunization

IntroductionThe mRNA platform has revolutionised vaccine technology by offering a universal, rapid, and easily scalable production process. Two main types of mRNA vectors exist—linear (cap‑dependent) and circular (cap‑independent)—each with distinct advantages. Although both vector types are continu...

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Hoofdauteurs: Vladimir M. Vakhtinskii, Irina L. Tutykhina, Alina S. Dzharullaeva, Daria M. Grousova, Ilya D. Zorkov, Anna A. Ilyukhina, Dmitrii A. Reshetnikov, Valentin V. Azizyan, Artem A. Derkaev, Evgeniia N. Bykonia, Evgeny V. Usachev, Denis A. Kleymenov, Vladimir A. Gushchin, Inna V. Shuliakova, Dmitry V. Shcheblyakov, Maxim M. Shmarov, Denis Yu. Logunov, Alexander L. Gintsburg
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2026-04-01
Reeks:Frontiers in Immunology
Onderwerpen:
ARCA
circular mRNA
circular mRNA-vaccine
CleanCap
CVB3 IRES
HRVB6 IRES
Online toegang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1734751/full
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