Major Role of S-Glycoprotein in Providing Immunogenicity and Protective Immunity in mRNA Lipid Nanoparticle Vaccines Based on SARS-CoV-2 Structural Proteins

SARS-CoV-2 variants have evolved over time in recent years, demonstrating immune evasion of vaccine-induced neutralizing antibodies directed against the original S protein. Updated S-targeted vaccines provide a high level of protection against circulating variants of SARS-CoV-2, but this protection...

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Hauptverfasser:	Evgeniia N. Bykonia, Denis A. Kleymenov, Vladimir A. Gushchin, Andrei E. Siniavin, Elena P. Mazunina, Sofia R. Kozlova, Anastasia N. Zolotar, Evgeny V. Usachev, Nadezhda A. Kuznetsova, Elena V. Shidlovskaya, Andrei A. Pochtovyi, Daria D. Kustova, Igor A. Ivanov, Sergey E. Dmitriev, Roman A. Ivanov, Denis Y. Logunov, Alexander L. Gintsburg
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2024-04-01
Schriftenreihe:	Vaccines
Schlagworte:	SARS-CoV-2 mRNA vaccine lipid nanoparticles immunogenicity efficacy
Online-Zugang:	https://www.mdpi.com/2076-393X/12/4/379
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