Glycan pairing in therapeutic IgG orchestrates Fcγ receptor engagement and ADCC: an integrated structure-function approach for thorough evaluation of Fc N-glycans as critical quality attributes

Monoclonal antibodies (mAbs) can mediate their therapeutic activity through antigen binding and by engaging Fc receptors (FcRs) or the complement system. FcRs are expressed on immune cells and can initiate effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-depend...

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Auteurs principaux:	Maximilian Meudt, Julia Baumeister, Antoinette Cassiopeia Russell, Lindsey Dzielak, Gale Hansen, Boris Mizaikoff, Sybille Ebert, Frank Rosenau, Michaela Blech, Fabian Higel
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis Group 2026-12-01
Collection:	mAbs
Sujets:	glycan pairing monoclonal antibody IgG N-glycosylation effector functions Antibody-dependent cellular cytotoxicity (ADCC)
Accès en ligne:	https://www.tandfonline.com/doi/10.1080/19420862.2026.2652642
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