Selective clearance of monoclonal antibodies via the mannose receptor is dependent on glycan pairing

Abstract The pharmacokinetics (PK) of therapeutic monoclonal antibodies (mAbs) are influenced by N-glycosylation, a critical quality attribute (CQA) that affects serum half-life and receptor interactions. High-mannose N-glycans are known to accelerate mAb clearance, likely via the mannose receptor (...

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Bibliografski detalji

Glavni autori:	Julia Baumeister, Maximilian Meudt, Wei Wei, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Lin-Zhi Chen, Fabian Higel
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2026-03-01
Serija:	Scientific Reports
Teme:	Monoclonal antibody Glycan pairing High-mannose Mannose receptor Internalization Pharmacokinetics
Online pristup:	https://doi.org/10.1038/s41598-026-40268-1
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