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Glycan pairing in therapeutic IgG orchestrates Fcγ receptor engagement and ADCC: an integrated structure-function approach for thorough evaluation of Fc N-glycans as critical quality attributes

Monoclonal antibodies (mAbs) can mediate their therapeutic activity through antigen binding and by engaging Fc receptors (FcRs) or the complement system. FcRs are expressed on immune cells and can initiate effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-depend...

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Principais autores: Maximilian Meudt, Julia Baumeister, Antoinette Cassiopeia Russell, Lindsey Dzielak, Gale Hansen, Boris Mizaikoff, Sybille Ebert, Frank Rosenau, Michaela Blech, Fabian Higel
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2026-12-01
coleção:mAbs
Assuntos:
glycan pairing
monoclonal antibody
IgG
N-glycosylation
effector functions
Antibody-dependent cellular cytotoxicity (ADCC)
Acesso em linha:https://www.tandfonline.com/doi/10.1080/19420862.2026.2652642
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