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Demethylation of leptin promoter in gestational diabetes mellitus: evidence from a mouse model

BackgroundGestational diabetes mellitus (GDM) has been linked to altered leptin (LEP) gene methylation, which may disrupt maternal glucose metabolism and the associated placental signaling. However, the changes of LEP methylation involved in GDM pathophysiology throughout pregnancy remain unclear.Me...

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Principais autores: Linlin Hu, Shihuang Liu, Lin Tu, Shupei Zhang, Xiaojing Huang, Hang Lin, Jianguang Ji, Huan Yi, Xiangqin Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-01-01
coleção:Frontiers in Cell and Developmental Biology
Assuntos:
gestational diabetes mellitus
glucose metabolism
leptin
methylation
mouse model
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2026.1729477/full
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