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Demethylation of leptin promoter in gestational diabetes mellitus: evidence from a mouse model

BackgroundGestational diabetes mellitus (GDM) has been linked to altered leptin (LEP) gene methylation, which may disrupt maternal glucose metabolism and the associated placental signaling. However, the changes of LEP methylation involved in GDM pathophysiology throughout pregnancy remain unclear.Me...

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Hlavní autoři: Linlin Hu, Shihuang Liu, Lin Tu, Shupei Zhang, Xiaojing Huang, Hang Lin, Jianguang Ji, Huan Yi, Xiangqin Zheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2026-01-01
Edice:Frontiers in Cell and Developmental Biology
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fcell.2026.1729477/full
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