Demethylation of leptin promoter in gestational diabetes mellitus: evidence from a mouse model

BackgroundGestational diabetes mellitus (GDM) has been linked to altered leptin (LEP) gene methylation, which may disrupt maternal glucose metabolism and the associated placental signaling. However, the changes of LEP methylation involved in GDM pathophysiology throughout pregnancy remain unclear.Me...

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Principais autores:	Linlin Hu, Shihuang Liu, Lin Tu, Shupei Zhang, Xiaojing Huang, Hang Lin, Jianguang Ji, Huan Yi, Xiangqin Zheng
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2026-01-01
סדרה:	Frontiers in Cell and Developmental Biology
נושאים:	gestational diabetes mellitus glucose metabolism leptin methylation mouse model
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1729477/full
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