Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury

Abstract Background Neuroinflammation and mitochondrial dysfunction play crucial roles in retinal ischemia and reperfusion (IR) injury. Recent studies have identified mitochondrial function as a promising target for immunomodulation. Empagliflozin (EMPA), an anti-diabetic drug, has exhibited great p...

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Váldodahkkit:	Zhenlan Yang, Yidan Liu, Xuhao Chen, Shaofen Huang, Yangyang Li, Guitong Ye, Xu Cao, Wenru Su, Yehong Zhuo
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2023-12-01
Ráidu:	Journal of Neuroinflammation
Fáttát:	Retinal ischemia and reperfusion injury Neuroinflammation Empagliflozin Mitofusin 1 Optic atrophy 1
Liŋkkat:	https://doi.org/10.1186/s12974-023-02982-9
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