Unveiling the Relationship between Ceftobiprole and High-Molecular-Mass (HMM) Penicillin-Binding Proteins (PBPs) in <i>Enterococcus faecalis</i>

Low-affinity PBP4, historically linked to penicillin resistance in <i>Enterococcus faecalis</i>, may still have affinity for novel cephalosporins. Ceftobiprole (BPR) is a common therapeutic choice, even with PBP4-related overexpression and amino acid substitution due to mutations. Our study aims to...

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Principais autores:	Paola Conti, Lorenzo Mattia Lazzaro, Fabio Longo, Federica Lenzo, Alessandra Giardina, Sebastiano Alberto Fortuna, Stefania Stefani, Floriana Campanile
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2024-01-01
Series:	Antibiotics
Assuntos:	<i>Enterococcus faecalis</i> ceftobiprole PBPs competition assays Bocillin
Acceso en liña:	https://www.mdpi.com/2079-6382/13/1/65
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