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Unveiling the Relationship between Ceftobiprole and High-Molecular-Mass (HMM) Penicillin-Binding Proteins (PBPs) in <i>Enterococcus faecalis</i>

Low-affinity PBP4, historically linked to penicillin resistance in <i>Enterococcus faecalis</i>, may still have affinity for novel cephalosporins. Ceftobiprole (BPR) is a common therapeutic choice, even with PBP4-related overexpression and amino acid substitution due to mutations. Our study aims to...

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Principais autores: Paola Conti, Lorenzo Mattia Lazzaro, Fabio Longo, Federica Lenzo, Alessandra Giardina, Sebastiano Alberto Fortuna, Stefania Stefani, Floriana Campanile
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-01-01
coleção:Antibiotics
Assuntos:
<i>Enterococcus faecalis</i>
ceftobiprole
PBPs
competition assays
Bocillin
Acesso em linha:https://www.mdpi.com/2079-6382/13/1/65
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