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Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay

Abstract Background Anti-cancer immune responses may contribute to the control of tumors after conventional chemotherapy, and different observations have indicated that chemotherapeutic agents can induce immune responses resulting in cancer cell death and immune-stimulatory side effects. Increasing...

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Principais autores: Maria Pia Abruzzese, Maria Teresa Bilotta, Cinzia Fionda, Alessandra Zingoni, Alessandra Soriani, Elisabetta Vulpis, Cristiana Borrelli, Beatrice Zitti, Maria Teresa Petrucci, Maria Rosaria Ricciardi, Rosa Molfetta, Rossella Paolini, Angela Santoni, Marco Cippitelli
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2016-12-01
coleção:Journal of Hematology & Oncology
Assuntos:
Multiple myeloma
Bromodomain
IRF4
Natural killer
NKG2DLs
Acesso em linha:http://link.springer.com/article/10.1186/s13045-016-0362-2
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