hapE and hmg1 Mutations Are Drivers of cyp51A-Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate

ABSTRACT Aspergillus fumigatus is a ubiquitous environmental mold that can cause severe disease in immunocompromised patients and chronic disease in individuals with underlying lung conditions. Triazoles are the most widely used class of antifungal drugs to treat A. fumigatus infections, but their u...

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Principais autores:	Ana C. O. Souza, Wenbo Ge, Nathan P. Wiederhold, Jeffrey M. Rybak, Jarrod R. Fortwendel, P. David Rogers
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2023-06-01
coleção:	Microbiology Spectrum
Assuntos:	Aspergillus fumigatus triazole drug resistance hmg1 hapE CCAAT box binding complex
Acesso em linha:	https://journals.asm.org/doi/10.1128/spectrum.05188-22
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