PTEN C-Terminal Deletion Causes Genomic Instability and Tumor Development

Tumor suppressor PTEN controls genomic stability and inhibits tumorigenesis. The N-terminal phosphatase domain of PTEN antagonizes the PI3K/AKT pathway, but its C-terminal function is less defined. Here, we describe a knockin mouse model of a nonsense mutation that results in the deletion of the ent...

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Autors principals:	Zhuo Sun, Chuanxin Huang, Jinxue He, Kristy L. Lamb, Xi Kang, Tingting Gu, Wen Hong Shen, Yuxin Yin
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2014-03-01
Col·lecció:	Cell Reports
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124714000643
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