PTEN C-Terminal Deletion Causes Genomic Instability and Tumor Development
Tumor suppressor PTEN controls genomic stability and inhibits tumorigenesis. The N-terminal phosphatase domain of PTEN antagonizes the PI3K/AKT pathway, but its C-terminal function is less defined. Here, we describe a knockin mouse model of a nonsense mutation that results in the deletion of the ent...
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| Автори: | , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Elsevier
2014-03-01
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| Серія: | Cell Reports |
| Онлайн доступ: | http://www.sciencedirect.com/science/article/pii/S2211124714000643 |
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