Chromosome length is constrained by spindle scaling to ensure faithful mitosis in mammals
Abstract Why eukaryotic genomes are universally divided among multiple chromosomes remains an unresolved question. Although yeast and mouse cells can tolerate chromosomal fusions without impairing viability, we show here that chromosome length in mammalian cells is constrained by a biophysical limit...
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| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer Nature
2026-01-01
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| Series: | Molecular Systems Biology |
| Assuntos: | |
| Acceso en liña: | https://doi.org/10.1038/s44320-026-00188-8 |
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