Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC li...

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Egile Nagusiak:	Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Wiley 2026-07-01
Saila:	Advanced Science
Gaiak:	alpha‐1 antitrypsin CCDC25 colorectal cancer liver metastasis neutrophil extracellular traps tumor microenvironment
Sarrera elektronikoa:	https://doi.org/10.1002/advs.202520000
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!