Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC li...

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Bibliografische gegevens

Hoofdauteurs:	Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Wiley 2026-07-01
Reeks:	Advanced Science
Onderwerpen:	alpha‐1 antitrypsin CCDC25 colorectal cancer liver metastasis neutrophil extracellular traps tumor microenvironment
Online toegang:	https://doi.org/10.1002/advs.202520000
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