Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC li...

Description complète

Détails bibliographiques

Auteurs principaux:	Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2026-07-01
Collection:	Advanced Science
Sujets:	alpha‐1 antitrypsin CCDC25 colorectal cancer liver metastasis neutrophil extracellular traps tumor microenvironment
Accès en ligne:	https://doi.org/10.1002/advs.202520000
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!