THBS1 Induces Dysfunction of Ovarian Granulosa Cells in Patients with Polycystic Ovary Syndrome by Activating the TGF-β/Smad Pathway

<b>Objective:</b> This study aims to investigate the role of thrombospondin-1 (THBS1) in polycystic ovary syndrome (PCOS) pathogenesis and its mechanism in regulating granulosa cell (GC) function. <b>Methods:</b> Follicular fluid and granulosa cells from 21 PCOS patients and 21 age-matched non-PCOS...

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Ngā kaituhi matua:	Jiajing He, Lirong Wang, Luni Tan, Xinyue Zhou, Xiaorong Luo, Wei Wang, Xuehong Zhang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2026-06-01
Rangatū:	Biomedicines
Ngā marau:	polycystic ovary syndrome THBS1 TGF-β1 Smad2 granulosa cell apoptosis
Urunga tuihono:	https://www.mdpi.com/2227-9059/14/6/1273
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!