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Resveratrol ameliorates myocardial fibrosis by regulating Sirt1/Smad3 deacetylation pathway in rat model with dilated cardiomyopathy

Abstract Background The aim of this study was to investigate the effects of Resveratrol (RSV) in rats with dilated cardiomyopathy (DCM). Methods Porcine cardiac myosin was used to set up rat model with DCM. RSV (10 mg/kg in RSV-L group and 50 mg/kg in RSV-H group) or vehicle was administered to rats...

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Principais autores: Qingquan Chen, Yu Zeng, Xiulin Yang, Yue Wu, Shuyu Zhang, Shirong Huang, Yameng Zhong, Min Chen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-01-01
coleção:BMC Cardiovascular Disorders
Assuntos:
Resveratrol
Fibrosis
Sirt1
Smad3
Dilated cardiomyopathy
Acesso em linha:https://doi.org/10.1186/s12872-021-02401-y
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