PLOD2 promotes proliferation, migration and invasion of colorectal cancer cells via PI3K-AKT-GSK3β signaling pathway

Abstract Colorectal cancer (CRC) progression critically depends on the tumor microenvironment. PLOD2, an enzyme involved in collagen biosynthesis, is highly expressed in many cancers. While it promotes CRC growth via the USP15–AKT/mTOR pathway, its role in enhancing tumor cell migration and invasion...

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Главные авторы:	Hua Fang, Jing Zheng, Shutong Ren, Danjing Chen, Yunli Wu, Xian-E Peng
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2026-02-01
Серии:	Scientific Reports
Предметы:	PLOD2 Colorectal cancer Malignant progression Metastasis PI3K-AKT- GSK3β
Online-ссылка:	https://doi.org/10.1038/s41598-026-38593-6
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