Jiedu Huoxue decoction inhibits cardiomyocyte apoptosis via PTEN/AKT/GSK3β-mediated mitochondrial dynamics in myocardial infarction: an integrative study of network pharmacology, transcriptomics and molecular docking

Abstract Background Myocardial infarction (MI) triggers oxidative stress, mitochondrial dysfunction, and cardiomyocyte apoptosis. At present, it remains urgently needed to develop novel therapies specifically suppressing cardiomyocyte apoptosis via improving mitochondrial dysfunction following MI. J...

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Autors principals:	Mingjie Pang, Han Peng, Changlei Hu, Yutong Li, Yangzhen Pei, Bin Liu, Yuting Wu, Guanghong Chen, Haozhen Cui, Aihua Shen, Li Zheng, Lingpeng Xie, Yingchun Zhou, Guoyong Zhang, Xin Han
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-06-01
Col·lecció:	Chinese Medicine
Matèries:	JDHXD Myocardial infarction Mitochondrial dynamics Cardiomyocyte apoptosis PTEN/AKT/GSK3β
Accés en línia:	https://doi.org/10.1186/s13020-026-01444-7
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