Structural bases for Na+-Cl− cotransporter inhibition by thiazide diuretic drugs and activation by kinases
Abstract The Na+-Cl− cotransporter (NCC) drives salt reabsorption in the kidney and plays a decisive role in balancing electrolytes and blood pressure. Thiazide and thiazide-like diuretics inhibit NCC-mediated renal salt retention and have been cornerstones for treating hypertension and edema since...
Tallennettuna:
| Päätekijät: | , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Portfolio
2024-08-01
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| Sarja: | Nature Communications |
| Linkit: | https://doi.org/10.1038/s41467-024-51381-y |
| Tagit: |
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