Structural bases for Na+-Cl− cotransporter inhibition by thiazide diuretic drugs and activation by kinases
Abstract The Na+-Cl− cotransporter (NCC) drives salt reabsorption in the kidney and plays a decisive role in balancing electrolytes and blood pressure. Thiazide and thiazide-like diuretics inhibit NCC-mediated renal salt retention and have been cornerstones for treating hypertension and edema since...
Збережено в:
| Автори: | , , , , , , |
|---|---|
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Nature Portfolio
2024-08-01
|
| Серія: | Nature Communications |
| Онлайн доступ: | https://doi.org/10.1038/s41467-024-51381-y |
| Теги: |
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|