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In vivo involvement of cytochrome P450 4A family in the oxidative metabolism of the lipid peroxidation product trans-4-hydroxy-2-nonenal, using PPARα-deficient mice

Trans-4-hydroxy-2-nonenal (HNE) is a potent cytotoxic and genotoxic compound originating from the peroxidation of n–6 polyunsaturated fatty acids. Its metabolism has been previously studied in the rat (Alary et al. 1995. Chem. Res. Toxicol., 8: 35–39). In addition to major urinary mercapturic deriva...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Françoise Guéraud, Jacques Alary, Philippe Costet, Laurent Debrauwer, Laurence Dolo, Thierry Pineau, Alain Paris
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 1999-01-01
Schriftenreihe:Journal of Lipid Research
Schlagworte:
4-HNE
PPARα
knockout mice
CYP 4A
ω-hydroxylation
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S0022227520333502
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