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Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal

4-Hydroxy-2-(E)-nonenal (4-HNE) is one of the major lipid peroxidation product formed during oxidative stress. At high concentrations, 4-HNE is cytotoxic and exerts deleterious effects that are often associated with the pathology of oxidative stress-driven disease. Alternatively, at low concentratio...

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Principais autores: Tonibelle N. Gatbonton-Schwager, Sushabhan Sadhukhan, Guo-Fang Zhang, John J. Letterio, Gregory P. Tochtrop
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2014-01-01
Serier:Redox Biology
Fag:
lipid peroxidation
4-HNE
iNOS
nitric oxide
Nrf2
Online adgang:http://www.sciencedirect.com/science/article/pii/S2213231714000627
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