Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein (RNP) to inhibit herpes simplex virus1 infection in vitro and in vivo

Extracellular vesicles (EVs) have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins (RNPs), owing to their ability to minimize off-target effects and immune responses. However, enhancements are required to boost the efficiency and safety of Cas9 RNP enrichment with...

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Autores principales:	Yuanda Wan, Liren Li, Ruilin Chen, Jiajia Han, Qiyun Lei, Zhipeng Chen, Xiaodong Tang, Wenyu Wu, Shuwen Liu, Xingang Yao
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2024-03-01
Colección:	Acta Pharmaceutica Sinica B
Materias:	Extracellular vesicles CRISPR/Cas9 Ribonucleoproteins PTGFRN Fc/Spa HSV1
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2211383523003878
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