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Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity

ABSTRACTAcetyl-CoA carboxylases (ACCs) convert acetyl-CoA to malonyl-CoA, a key step in fatty acid biosynthesis and autotrophic carbon fixation pathways. Three functionally distinct components, biotin carboxylase (BC), biotin carboxyl carrier protein (BCCP), and carboxyltransferase (CT), are either...

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Principais autores: Jiejie Shen, Wenping Wu, Kangle Wang, Jingyi Wu, Bing Liu, Chunyang Li, Zijun Gong, Xin Hong, Han Fang, Xingwei Zhang, Xiaoling Xu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2024-05-01
Serier:mBio
Fag:
acetyl-CoA carboxylase
biotin carboxylase
biotin carboxyl carrier protein
carboxyltransferase
3-hydroxypropionate
Online adgang:https://journals.asm.org/doi/10.1128/mbio.03414-23
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