Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease[S]

Lysosomal acid lipase (LAL) is a serine hydrolase that hydrolyzes cholesteryl ester (CE) and TGs delivered to the lysosomes into free cholesterol and fatty acids. LAL deficiency due to mutations in the LAL gene (LIPA) results in accumulation of TGs and cholesterol esters in various tissues of the bo...

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Үндсэн зохиолчид:	Francis Rajamohan, Allan R. Reyes, Meihua Tu, Nicole L. Nedoma, Lise R. Hoth, Adam G. Schwaid, Ravi G. Kurumbail, Jessica Ward, Seungil Han
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2020-08-01
Цуврал:	Journal of Lipid Research
Нөхцлүүд:	lysosomal acid lipase deficiency Wolman's disease lipid metabolism protein aggregation molecular dynamic simulations
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S0022227520434881
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!