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Depdc5 knockout rat: A novel model of mTORopathy

DEP-domain containing 5 (DEPDC5), encoding a repressor of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, has recently emerged as a major gene mutated in familial focal epilepsies and focal cortical dysplasia. Here we established a global knockout rat using TALEN technology...

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Principais autores: Elise Marsan, Saeko Ishida, Adrien Schramm, Sarah Weckhuysen, Giuseppe Muraca, Sarah Lecas, Ning Liang, Caroline Treins, Mario Pende, Delphine Roussel, Michel Le Van Quyen, Tomoji Mashimo, Takehito Kaneko, Takashi Yamamoto, Tetsushi Sakuma, Séverine Mahon, Richard Miles, Eric Leguern, Stéphane Charpier, Stéphanie Baulac
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016-05-01
Colecção:Neurobiology of Disease
Assuntos:
DEPDC5
Familial focal epilepsy
Focal cortical dysplasia
mTOR
Rapamycin
Knockout
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996116300316
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