Depdc5 knockout rat: A novel model of mTORopathy

DEP-domain containing 5 (DEPDC5), encoding a repressor of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, has recently emerged as a major gene mutated in familial focal epilepsies and focal cortical dysplasia. Here we established a global knockout rat using TALEN technology...

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Bibliografiska uppgifter

Huvudupphov:	Elise Marsan, Saeko Ishida, Adrien Schramm, Sarah Weckhuysen, Giuseppe Muraca, Sarah Lecas, Ning Liang, Caroline Treins, Mario Pende, Delphine Roussel, Michel Le Van Quyen, Tomoji Mashimo, Takehito Kaneko, Takashi Yamamoto, Tetsushi Sakuma, Séverine Mahon, Richard Miles, Eric Leguern, Stéphane Charpier, Stéphanie Baulac
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Elsevier 2016-05-01
Serie:	Neurobiology of Disease
Ämnen:	DEPDC5 Familial focal epilepsy Focal cortical dysplasia mTOR Rapamycin Knockout
Länkar:	http://www.sciencedirect.com/science/article/pii/S0969996116300316
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