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Depdc5 knockout rat: A novel model of mTORopathy

DEP-domain containing 5 (DEPDC5), encoding a repressor of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, has recently emerged as a major gene mutated in familial focal epilepsies and focal cortical dysplasia. Here we established a global knockout rat using TALEN technology...

Бүрэн тодорхойлолт

-д хадгалсан:
Үндсэн зохиолчид: Elise Marsan, Saeko Ishida, Adrien Schramm, Sarah Weckhuysen, Giuseppe Muraca, Sarah Lecas, Ning Liang, Caroline Treins, Mario Pende, Delphine Roussel, Michel Le Van Quyen, Tomoji Mashimo, Takehito Kaneko, Takashi Yamamoto, Tetsushi Sakuma, Séverine Mahon, Richard Miles, Eric Leguern, Stéphane Charpier, Stéphanie Baulac
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Elsevier 2016-05-01
Цуврал:Neurobiology of Disease
Нөхцлүүд:
DEPDC5
Familial focal epilepsy
Focal cortical dysplasia
mTOR
Rapamycin
Knockout
Онлайн хандалт:http://www.sciencedirect.com/science/article/pii/S0969996116300316
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