Synthesis, Physicochemical, Labeling and In Vivo Characterization of ⁴⁴Sc-Labeled DO3AM-NI as a Hypoxia-Sensitive PET Probe

Hypoxia promotes angiogenesis, which is crucial for tumor growth, and induces malignant progression and increases the therapeutic resistance. Positron emission tomography (PET) enables the detection of the hypoxic regions in tumors using 2-nitroimidazole-based radiopharmaceuticals. We describe here...

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Autors principals:	Dániel Szücs, Tibor Csupász, Judit P. Szabó, Adrienn Kis, Barbara Gyuricza, Viktória Arató, Viktória Forgács, Adrienn Vágner, Gábor Nagy, Ildikó Garai, Dezső Szikra, Imre Tóth, György Trencsényi, Gyula Tircsó, Anikó Fekete
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-05-01
Col·lecció:	Pharmaceuticals
Matèries:	radiopharmaceutical physicochemical study scandium-44 radiochemistry positron emission tomography tumor hypoxia
Accés en línia:	https://www.mdpi.com/1424-8247/15/6/666
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