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Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity

Multidrug-resistant tuberculosis (MDR-TB) poses a significant threat to mankind and as such earned its place on the WHO list of priority pathogens. New antimycobacterials with a mechanism of action different to currently used agents are highly required. This study presents the design, synthesis, and...

Deskribapen osoa

Gorde:
Egile Nagusiak: Vinod Sukanth Kumar Pallabothula, Marek Kerda, Martin Juhás, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Pavla Paterová, Jan Zitko
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI AG 2022-10-01
Saila:Biomolecules
Gaiak:
3-aminopyrazinamide
antibacterial
antimycobacterial
homology model
molecular dynamics
prolyl-tRNA synthetase
Sarrera elektronikoa:https://www.mdpi.com/2218-273X/12/11/1561
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