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Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1

Abstract Prolyl‐tRNA synthetase 1 (PARS1) has attracted much interest in controlling pathologic accumulation of collagen containing high amounts of proline in fibrotic diseases. However, there are concerns about its catalytic inhibition for potential adverse effects on global protein synthesis. We d...

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Principais autores: Ina Yoon, Sulhee Kim, Minjae Cho, Kyung Ah You, Jonghyeon Son, Caroline Lee, Ji Hun Suh, Da‐Jeong Bae, Jong Min Kim, Sinae Oh, Songhwa Park, Sanga Kim, Seong Hyeok Cho, Seonha Park, Kyuhyeon Bang, Minjeong Seo, Jong Hyun Kim, Bongyong Lee, Joon Seok Park, Kwang Yeon Hwang, Sunghoon Kim
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Nature 2023-05-01
coleção:EMBO Molecular Medicine
Assuntos:
collagen
drug development
fibrosis
prolyl‐tRNA synthetase 1
Acesso em linha:https://doi.org/10.15252/emmm.202216940
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