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Dual-mode recognition of tRNAPro isoacceptors by Toxoplasma gondii Prolyl-tRNA synthetase

Abstract Prolyl-tRNA synthetases (ProRSs) exhibit diverse domain architectures and motifs, evolving into prokaryotic (P-type) and eukaryotic/archaeal (E-type) variants. Both types exhibit high specificity for the recognition and aminoacylation of their cognate tRNAs. Interestingly, the parasitic euk...

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Principais autores: Indira Rizqita Ivanesthi, Emi Latifah, Shih-Yang Liu, Yi-Kuan Tseng, Hung-Chuan Pan, Chien-Chia Wang
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2025-04-01
Serier:EMBO Reports
Fag:
Aminoacyl-tRNA Synthetase
Halofuginone
Parasite
Protein Synthesis
Toxoplasmosis
Online adgang:https://doi.org/10.1038/s44319-025-00457-x
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