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Modulation of the RNA Interference Activity Using Central Mismatched siRNAs and Acyclic Threoninol Nucleic Acids (aTNA) Units

The understanding of the mechanisms behind nucleotide recognition by Argonaute 2, core protein of the RNA-induced silencing complex, is a key aspect in the optimization of small interfering RNAs (siRNAs) activity. To date, great efforts have been focused on the modification of certain regions of siR...

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Príomhchruthaitheoirí: Adele Alagia, Montserrat Terrazas, Ramon Eritja
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: MDPI AG 2015-04-01
Sraith:Molecules
Ábhair:
Rochtain ar líne:http://www.mdpi.com/1420-3049/20/5/7602
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