Modulation of the RNA Interference Activity Using Central Mismatched siRNAs and Acyclic Threoninol Nucleic Acids (aTNA) Units

The understanding of the mechanisms behind nucleotide recognition by Argonaute 2, core protein of the RNA-induced silencing complex, is a key aspect in the optimization of small interfering RNAs (siRNAs) activity. To date, great efforts have been focused on the modification of certain regions of siR...

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Detalhes bibliográficos

Principais autores:	Adele Alagia, Montserrat Terrazas, Ramon Eritja
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2015-04-01
Colecção:	Molecules
Assuntos:	RNAi siRNA single-stranded siRNA L-threoninol Ago2 RISC silencing asymmetry wobble base pair on-/off-target effects central mismatched siRNA
Acesso em linha:	http://www.mdpi.com/1420-3049/20/5/7602
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