Modulation of the RNA Interference Activity Using Central Mismatched siRNAs and Acyclic Threoninol Nucleic Acids (aTNA) Units

The understanding of the mechanisms behind nucleotide recognition by Argonaute 2, core protein of the RNA-induced silencing complex, is a key aspect in the optimization of small interfering RNAs (siRNAs) activity. To date, great efforts have been focused on the modification of certain regions of siR...

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Principais autores:	Adele Alagia, Montserrat Terrazas, Ramon Eritja
格式:	Artigo
語言:	Inglês
出版:	MDPI AG 2015-04-01
叢編:	Molecules
主題:	RNAi siRNA single-stranded siRNA L-threoninol Ago2 RISC silencing asymmetry wobble base pair on-/off-target effects central mismatched siRNA
在線閱讀:	http://www.mdpi.com/1420-3049/20/5/7602
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