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The HIV-1 Vpr R77Q mutant alters host apoptotic gene regulation in CD4+ T cells

IntroductionHIV-1 viral protein R (Vpr) is a multifunctional accessory protein that modulates host cellular pathways and contributes to viral pathogenesis. The HIV-1 Vpr R77Q polymorphism is enriched in long-term non-progressors (LTNPs) and has been associated with reduced overall cell death and a s...

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Principais autores: Sidney T. Sithole, Joshua Ramsey, Macey C. Call, Kenneth K. K. Ewool, Brian D. Poole, Brett E. Pickett, Bradford K. Berges
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-06-01
coleção:Frontiers in Cellular and Infection Microbiology
Assuntos:
AIDS
apoptosis
HIV
host–virus interaction
RNA sequencing
transcriptomics
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcimb.2026.1830094/full
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