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Dysregulation of coordinated neuronal firing patterns in striatum of freely behaving transgenic rats that model Huntington's disease

Altered neuronal activity in the striatum appears to be a key component of Huntington's disease (HD), a fatal, neurodegenerative condition. To assess this hypothesis in freely behaving transgenic rats that model HD (tgHDs), we used chronically implanted micro-wires to record the spontaneous activity...

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Principais autores: Benjamin R. Miller, Adam G. Walker, Stephen C. Fowler, Stephan von Hörsten, Olaf Riess, Michael A. Johnson, George V. Rebec
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2010-01-01
Serier:Neurobiology of Disease
Fag:
Huntington's disease
Transgenic
Rat
Striatum
Medium spiny neurons
Electrophysiology
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996109002654
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