Pericellular heparan sulfate proteoglycans: Role in regulating the biosynthetic response of nucleus pulposus cells to osmotic loading

Abstract Background Daily physiologic loading causes fluctuations in hydration of the intervertebral disc (IVD); thus, the embedded cells experience cyclic alterations to their osmotic environment. These osmotic fluctuations have been described as a mechanism linking mechanics and biology, and have...

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Autori principali:	Carly M. Krull, Jordan Rife, Brett Klamer, Devina Purmessur, Benjamin A. Walter
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2022-06-01
Serie:	JOR Spine
Soggetti:	heparan sulfate proteoglycan intervertebral disc mechanotransduction nucleus pulposus osmotic pericellular matrix
Accesso online:	https://doi.org/10.1002/jsp2.1209
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