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Targeting monopolar spindle kinase I (Mps1 or TTK) induces radiosensitization in syngeneic models of triple negative breast cancer (TNBC) and potentiates type I interferon (T1IFN) signaling

Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately impacts Black women and has limited effective therapeutic options. Consequently, there is an urgent need to develop novel approaches for the treatment of TNBC. Previously, we identified monopolar spin...

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Principais autores: Kassidy M. Jungles, Caroline R. Bishop, Cydnee M. Wilson, Meilan Liu, Kalli R. Jungles, Kari Wilder-Romans, Corey W. Speers, Lori J. Pierce, James M. Rae
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-08-01
Serier:Neoplasia: An International Journal for Oncology Research
Fag:
Monopolar spindle kinase I
Radiotherapy
Radiosensitization
Type I interferon
Breast cancer
Online adgang:http://www.sciencedirect.com/science/article/pii/S1476558625000697
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